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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
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NCBI BLAST+ integrated into Galaxy.

Peter J A Cock1, John M Chilton2, Björn Grüning3

  • 1Information and Computational Sciences, James Hutton Institute, Invergowrie, Dundee, DD2 5DA Scotland UK.

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|September 4, 2015
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Summary
This summary is machine-generated.

The National Center for Biotechnology Information Basic Local Alignment Search Tool (NCBI BLAST) suite is now integrated into the Galaxy platform. This integration simplifies sequence comparison workflows for molecular biology research and data analysis.

Keywords:
AccessibilityAnnotationBLASTGalaxyPipelineReproducibilitySequence analysisWorkflow

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Molecular Biology

Background:

  • The NCBI BLAST suite is a widely used tool in molecular biology for tasks ranging from sequencing results verification to genome-wide analyses.
  • Integrating BLAST into the Galaxy web-based platform was a logical progression for users performing sequence comparison workflows.

Purpose of the Study:

  • To integrate the NCBI BLAST+ command-line tool suite into the Galaxy analysis platform.
  • To facilitate common and advanced sequence comparison tasks within a web-based environment.

Main Methods:

  • The NCBI BLAST+ command-line tool suite was adapted for use within the Galaxy framework.
  • Custom datatypes were developed to support BLAST+ functionalities in Galaxy.

Main Results:

  • The BLAST+ tool suite is now available on Galaxy servers worldwide.
  • The integration enables both straightforward and complex BLAST analyses through the Galaxy interface.

Conclusions:

  • This collaborative effort has successfully deployed BLAST+ on global Galaxy servers.
  • The integration enhances sequence analysis capabilities for the bioinformatics community.