Related Experiment Videos
The development of a short route to the API ropinirole hydrochloride
Zeshan Yousuf1, Andrew K Richards, Andrew N Dwyer
1Chemistry, University of Southampton, Highfield, Southampton, Hampshire SO17 1BJ, UK. dch2@soton.ac.uk.
Organic & Biomolecular Chemistry
|September 5, 2015
Abstract:
A four-step, three-stage synthesis of the API ropinirole hydrochloride has been developed from a commercially available naphthalene derivative. The new route has half the step-count and twice the overall yield of the current manufacturing process. Key features of the synthesis are a regioselective Birch reduction and an ozonolysis with concomitant ring closure to induce the required ring contraction.