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Updated: Apr 4, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Perioperative use of antibiotics in otologic procedures
1Department of Otolaryngology, University of Florida, Gainesville, Florida, USA.
Purpose Of Review:
Surgical site infections (SSIs) have garnered tremendous attention in recent years. Surgeons tend to administer antimicrobial agents liberally, partly over fears of being sued or not paid to care for the SSI. As a result, microbial resistance to conventional agents continues to increase.
Recent Findings:
Few new studies have been published in the otologic literature. The use of perioperative 'bundles' has been shown to be effective in reducing SSIs in procedures such as craniotomy. A single dose of antistaphylococcal and antipseudomonal prophylaxis appears to be highly efficacious prior to contaminated tympanomastoid surgery. Overuse of antimicrobial therapy can paradoxically increase SSIs.
Summary:
Otologic surgeons should adhere to established best practices when prescribing antimicrobial therapy perioperatively. Clinical trials of perioperative bundles are needed for otologic procedures.
Insights
To reduce surgical site infections (SSIs), otologic surgeons should use evidence-based antimicrobial stewardship. Overuse of antibiotics can increase SSIs, necessitating adherence to best practices and further research into perioperative bundles.
Area of Science:
- Otolaryngology
- Infectious Disease
- Surgical Innovation
Background:
- Surgical site infections (SSIs) are a growing concern in otologic surgery.
- Liberal use of antimicrobials by surgeons, driven by fear of litigation or payment issues, contributes to increasing microbial resistance.
- The rise in antimicrobial resistance poses a significant challenge to effective patient care.
Purpose of the Study:
- To review current strategies for preventing SSIs in otologic procedures.
- To evaluate the impact of antimicrobial stewardship on microbial resistance.
- To identify best practices for perioperative antimicrobial use in otology.
Main Methods:
- Review of recent literature on SSIs in otologic surgery.
- Analysis of the efficacy of perioperative antimicrobial strategies.
- Evaluation of the role of antimicrobial stewardship programs.
Main Results:
- Limited new studies in otologic literature, but perioperative 'bundles' show promise in reducing SSIs, as seen in craniotomy procedures.
- A single dose of antistaphylococcal and antipseudomonal prophylaxis is effective before contaminated tympanomastoid surgery.
- Paradoxically, overuse of antimicrobial therapy can lead to an increase in SSIs.
Conclusions:
- Otologic surgeons must adopt established best practices for perioperative antimicrobial prescribing.
- Further clinical trials are necessary to validate the effectiveness of perioperative bundles specifically for otologic procedures.
- Implementing antimicrobial stewardship is crucial to combat resistance and improve patient outcomes.
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