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Updated: Apr 4, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Medical Evaluation for Exposure Extremes: Heat
Riana R Pryor1, Brad L Bennett, Francis G OʼConnor
1*Department of Kinesiology, Korey Stringer Institute, University of Connecticut, Storrs, Connecticut; †Military & Emergency Medicine Department, F. Hébert School of Medicine, Bethesda, Maryland; ‡Uniformed Services University of the Health Sciences, Bethesda, Maryland; §Department of Family Medicine and Community Health, Division of Sports Medicine, John A. Burns School of Medicine, University of Hawaii, Mililani, Hawaii; and ¶Department of Family Medicine, Georgia Regents University, Augusta, Georgia.
Exertional heat illness is a risk during hot weather exercise. Understanding risk factors and mitigation strategies is key for safe participation in outdoor activities.
Area of Science:
- Sports Medicine
- Environmental Physiology
- Exercise Science
Background:
- Exertional heat illness poses significant risks during physical activity in hot climates.
- Both individual (intrinsic) and environmental (extrinsic) factors contribute to heat-related illness.
- Effective management requires understanding the underlying physiology and pathology.
Purpose of the Study:
- To review the risk factors associated with exertional heat illness.
- To outline strategies for preventing and mitigating heat accumulation during exercise.
- To provide guidance for practitioners and participants engaging in activities in hot environments.
Main Methods:
- Literature review of exertional heat illness.
- Analysis of intrinsic and extrinsic risk factors.
- Synthesis of heat illness prevention and management strategies.
Main Results:
- Identified key physiological and pathological mechanisms of heat illness.
- Detailed various intrinsic risk factors (e.g., fitness level, hydration status) and extrinsic factors (e.g., ambient temperature, humidity).
- Summarized effective strategies including acclimatization, hydration, and appropriate clothing.
Conclusions:
- Comprehensive knowledge of heat illness is crucial for athletes and organizers.
- Proactive identification and mitigation of risk factors enhance safety.
- Preparedness enables safe and enjoyable participation in strenuous activities in hot conditions.
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