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Published on: April 21, 2017
Clinical presentation, etiology, and outcome of stroke in children: A hospital-based study
Amira Masri1, Iyad Al-Ammouri2
1Department of Pediatrics, Division of Child Neurology, Faculty of Medicine, The University of Jordan, Jordan.
Insights
Pediatric stroke in Jordan is often caused by inherited metabolic disorders, cardiac issues, and coagulopathy. These conditions contribute to recurrent strokes and lasting neurological deficits in children.
Area of Science:
- Pediatric Neurology
- Clinical Genetics
- Vascular Neurology
Background:
- Stroke in children is a significant cause of long-term disability.
- Understanding the specific etiologies and outcomes in different populations is crucial for targeted interventions.
Purpose of the Study:
- To delineate the clinical features, underlying causes, and treatment outcomes of stroke in Jordanian children.
- To highlight the role of inherited disorders in pediatric stroke within this region.
Main Methods:
- Retrospective review of medical records for children diagnosed with ischemic stroke.
- Exclusion of neonatal stroke cases.
- Analysis of clinical presentations, identified etiologies, and patient outcomes over a follow-up period.
Main Results:
- Twenty-four children (aged 1 month to 13 years) were analyzed.
- Hemiparesis was the most common presentation (58.3%).
- Identified etiologies included metabolic disorders (25%), cardiac disorders (17%), and coagulopathy (17%).
- Recurrence of stroke (clinical and silent) occurred in 46% of patients.
- Residual motor weakness (58.3%) and epilepsy (29.2%) were common sequelae.
Conclusions:
- Metabolic disorders, cardiac conditions, and coagulopathies are primary drivers of stroke in Jordanian children.
- The study underscores the significant contribution of inherited disorders to pediatric stroke in Jordan.
Aim:
To describe clinical presentations, etiologies, and outcomes of stroke in Jordanian children.
Patients And Methods:
We retrospectively reviewed the medical records of children diagnosed with ischemic stroke who presented to our clinic from January 2001 to June 2014. Patients with onset of stroke in the neonatal period were excluded.
Results:
Twenty-four children (12 boys and 12 girls, with a male to female ratio of 1:1) were included in this study. The follow-up period ranged from 1 month to 9 years. Age at onset of the first stroke ranged from 1 month to 13 years. The most common initial clinical presentation was hemiparesis (58.3%). A known etiology was identified in 58.3% of patients. The most common etiologies were metabolic disorders, such as mitochondrial encephalopathy lactic acidosis and stroke (MELAS) and homocystinuria (25%), cardiac disorders (17%), and coagulopathy, such as a homozygous mutation in the MTHFR gene and a factor V Leiden mutation (17%). Recurrence of both clinical and silent strokes occurred in 46% of patients, residual motor weakness occurred in 58.3%, and residual epilepsy occurred in 29.2%.
Conclusion:
Metabolic disorders, cardiac disorders, and coagulopathy are the causes of strokes in Jordanian children. Our results emphasized the importance of inherited disorders in Jordan.
