Insights into the structure and function of membrane-integrated processive glycosyltransferases
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Updated: Apr 4, 2026

Generation of Null Mutants to Elucidate the Role of Bacterial Glycosyltransferases in Bacterial Motility
Published on: March 11, 2022
Yunchen Bi1, Caitlin Hubbard1, Pallinti Purushotham1
1Center for Membrane Biology, Department of Molecular Physiology and Biological Physics, University of Virginia, 480 Ray C. Hunt Dr., Charlottesville, VA 22908, United States.
Abstract:
Complex carbohydrates perform essential functions in life, including energy storage, cell signaling, protein targeting, quality control, as well as supporting cell structure and stability. Extracellular polysaccharides (EPS) represent mainly structural polymers and are found in essentially all kingdoms of life. For example, EPS are important biofilm and capsule components in bacteria, represent major constituents in cell walls of fungi, algae, arthropods and plants, and modulate the extracellular matrix in vertebrates. Different mechanisms evolved by which EPS are synthesized. Here, we review the structures and functions of membrane-integrated processive glycosyltransferases (GTs) implicated in the synthesis and secretion of chitin, alginate, hyaluronan and poly-N-acetylglucosamine (PNAG).
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