Functional coupling of the stabilizing gaze reflexes during vertical linear motion in the alert cat

Eye-head coordination is mainly achieved by means of stabilizing reflexes (VOR, VCR, OKR) and orienting movements (eye-neck surgery) underlying the close cooperation of the visual and vestibular systems in gaze stabilization. The functional coupling of these different sensorimotor subsystems has been principally analysed using rotatory stimulation of the whole body and/or of the visual surround. The aim of the present study was to investigate the dynamic properties of these stabilizing gaze reflexes and their coupling during linear motion in the vertical plane. These investigations were performed in the alert cat under open-loop conditions (head fixed). Otolith stimulation consisted of vertically translating the cat in total darkness using sinusoidal linear motion (0.025 Hz-1.39 Hz; 290 mm peak-to-peak amplitude). Optokinetic stimulation was provided by sinusoidally moving a pseudo-random visual pattern in front of the cat and in the vertical plane, with identical kinematic parameters. Normal visual-otolith interaction was performed by translating the cat in front of the stationary visual surround while conflicting interaction was provided by moving the animal and the visual pattern in phase and at the same velocity (visual stabilization). Results showed that the vertical otolith-neck reflex is very poorly developed or absent in the low frequency range of motion (0.025 Hz-0.25 Hz) while consistent EMG activity is found during pure optokinetic stimulation. EMG responses are in phase with the visual surround velocity in the upward direction and with the upward OKR velocity. A close correlation is observed between the EMG gain and the OKR gain, which both decrease in this low frequency range, indicating that gaze stabilization would be mainly ensured by the OKR and a functional oculo-collic coupling or eye-neck surgery in the vertical plane. On the contrary, gaze stabilization is principally achieved by way of the otolith-neck reflex in the higher frequency range of motion (above 0.25 Hz). EMG responses recorded during otolith stimulation exhibit a relatively constant gain and a phase lead with respect to motion velocity which progressively reduces as the stimulus frequency increases up to 1.39 Hz. When present, EMG responses evoked during the optokinetic stimulation show strong gain attenuation and phase lag. Normal visual-otolith interaction induces neck muscle activity which parallels the optokinetic and the otolith responses in the low and high frequency ranges, respectively. The motor responses are however improved in terms of gain and phase values in the whole frequency range when both sensory inputs are combined.(ABSTRACT TRUNCATED AT 400 WORDS)