Related Experiment Video
Updated: Apr 4, 2026
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
Antimicrobial resistance: a global multifaceted phenomenon
Francesca Prestinaci1, Patrizio Pezzotti, Annalisa Pantosti
1Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità , Rome, Italy.
Abstract:
Antimicrobial resistance (AMR) is one of the most serious global public health threats in this century. The first World Health Organization (WHO) Global report on surveillance of AMR, published in April 2014, collected for the first time data from national and international surveillance networks, showing the extent of this phenomenon in many parts of the world and also the presence of large gaps in the existing surveillance. In this review, we focus on antibacterial resistance (ABR), which represents at the moment the major problem, both for the high rates of resistance observed in bacteria that cause common infections and for the complexity of the consequences of ABR. We describe the health and economic impact of ABR, the principal risk factors for its emergence and, in particular, we illustrate the highlights of four antibiotic-resistant pathogens of global concern - Staphylococcus aureus, Klebsiella pneumoniae, non-typhoidal Salmonella and Mycobacterium tuberculosis - for whom we report resistance data worldwide. Measures to control the emergence and the spread of ABR are presented.
Insights
Antimicrobial resistance (AMR) is a major global health threat. This review details antibacterial resistance (ABR) impacts, risk factors, and control measures for key pathogens like Staphylococcus aureus and Mycobacterium tuberculosis.
Area of Science:
- Public Health
- Infectious Diseases
- Microbiology
Background:
- Antimicrobial resistance (AMR) is a critical global health challenge.
- The World Health Organization (WHO) 2014 report highlighted widespread AMR and surveillance gaps.
- Antibacterial resistance (ABR) is a primary concern due to high resistance rates and severe consequences.
Purpose of the Study:
- To review the health and economic impact of antibacterial resistance (ABR).
- To identify principal risk factors for the emergence and spread of ABR.
- To present worldwide resistance data for key antibiotic-resistant pathogens and discuss control measures.
Main Methods:
- Literature review focusing on global surveillance data of AMR and ABR.
- Analysis of health and economic impacts associated with ABR.
- Compilation and presentation of resistance data for specific pathogens.
Main Results:
- High rates of resistance are observed in bacteria causing common infections.
- Significant health and economic burdens are linked to ABR.
- Worldwide resistance data for Staphylococcus aureus, Klebsiella pneumoniae, non-typhoidal Salmonella, and Mycobacterium tuberculosis are presented.
Conclusions:
- ABR poses a substantial threat requiring urgent attention.
- Understanding risk factors is crucial for developing effective control strategies.
- Implementing control measures is essential to combat the emergence and spread of ABR.
More Related Videos
Related Concept Videos
01:30Development of Antibiotic Resistance
01:25Mechanism of Antibiotic Resistance in MRSA
01:25Clinical Significance of Antibiotic Resistance
00:57Antibiotic Selection
01:28Antimicrobial Effectiveness
01:31Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...