Related Experiment Videos
Negative inotropic and calcium antagonistic activity of alkyl and arylalkyl phosphonates
C Bellucci1, F Gualtieri, S Scapecchi
1Dipartimento di Scienze Farmaceutiche dell'Universita, Firenze, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|December 1, 1989
Abstract:
Several alkyl and arylalkyl diethylphosphonates related to fostedil have been synthetized and tested for negative inotropic activity (isolated guinea pig left atrium) and Ca++ antagonistic activity (isolated guinea pig aortic strips). The results show that negative inotropic and Ca++ antagonistic activity might depend from different molecular features.