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Orthotopic Left Lung Transplantation in Rats
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Double lung transplant in primate.

H K Hsu, M H Huang

    Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed
    |November 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    En-bloc double lung transplantation in cynomolgus monkeys showed technical feasibility. While survival was limited, bypass techniques offered smoother perioperative courses, indicating potential for future clinical trials.

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    Area of Science:

    • Surgical innovation
    • Transplantation research
    • Primate models

    Background:

    • En-bloc double lung transplantation (EDLT) was introduced to expand transplantation indications.
    • Previous acute models in puppies showed limitations; primates offer better survival prediction.
    • Taiwanese cynomolgus monkeys were utilized as a primate model for EDLT.

    Purpose of the Study:

    • To evaluate the technical feasibility of en-bloc double lung transplantation in primates.
    • To compare two preservation methods: surface cooling with profound hypothermia versus cardiopulmonary bypass.
    • To identify complications and challenges for future clinical application.

    Main Methods:

    • Twenty en-bloc double lung transplants were performed on Taiwan cynomolgus monkeys (2.4-8.0 kg).
    • Animals were divided into two groups: surface cooling/profound hypothermia and cardiopulmonary bypass (heart-lung machine).
    • Perioperative parameters, ischemic times, and survival outcomes were recorded.

    Main Results:

    • The surface cooling group experienced high mortality (5/10 on table) with the longest survivor living only 8 hours.
    • The bypass group had a smoother perioperative course and restored respiratory function.
    • Postoperative bleeding was a major complication in the bypass group; all animals died within 24 hours.
    • Intraoperative findings included evidence of tuberculosis and filariasis.

    Conclusions:

    • En-bloc double lung transplantation is technically feasible in cynomolgus monkeys.
    • Cardiopulmonary bypass appears to be a more viable method for lung preservation compared to surface cooling.
    • Further research is needed to address complications like bleeding and infections before clinical trials can commence.