[Serum lipid levels in hypercholesterolemic children after 5 years]

From a group of 1012 10-14-years-old children, incl. 724 with a positive and 288 with a negative cardiovascular history 56 (5.5%) had serum cholesterol values within the range of 5.0-6.47 mmol/l and were described as hypercholesterolaemic. Of these 39 (5.4%) had a positive and 17 (5.8%) a negative history. After five years the authors assessed in 46 the CHOL, HDL-C, LDL-C and calculated atherogenic indices. This time interval that except for the LDL-C and LDL-C:T-CHOL ratio the values of all parameters declined. The authors found a significant mean decline of T-CHOL by 0.457 mmol, and in HDL-C by 0.496 mmol/l; in LDL-C there was a mean increase by 0.0065 mmol/l, which was not significant. T-CHOL declined in 31% and HDL-C in 71% of the investigated subjects. These changes have to be considered when enlisting people into dispensary care. When testing by the entire group all parameters and their changes depend significantly on the initial values. In subjects with a positive cardiovascular history and HDL-C values lower than 1.11 mmol/l after five years a rise was recorded, and in those with values above 1.11 mmol/l a decline occurred. In subjects with a negative cardiovascular history HDL-C declined by 0.7 mmol/l in the entire range of investigated values.