Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

403
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
403
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

766
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
766

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AI/ML in drug product development & manufacturing - report on the 8th APV Winter conference.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same author

Effect of tablet press residence time distribution on material traceability in a continuous direct compression process via mini-batch blending - part 1: corroboration and application.

International journal of pharmaceutics·2026
Same author

Real-time monitoring of multiparticulate coating processes at industrial-scale using ultra-high-resolution optical coherence tomography.

International journal of pharmaceutics·2025
Same author

Kinetics of elastic recovery in roll compaction.

International journal of pharmaceutics: X·2024
Same author

Corrigendum to "Evaluation of binders in twin-screw wet granulation - Optimization of tabletability" [Int. J. Pharm. 659 (2024) 124290].

International journal of pharmaceutics·2024
Same author

Correction: Croscarmellose Sodium as Pelletization Aid in Extrusion-Spheronization.

AAPS PharmSciTech·2024

Related Experiment Video

Updated: Apr 4, 2026

In situ Grazing Incidence Small Angle X-ray Scattering on Roll-To-Roll Coating of Organic Solar Cells with Laboratory X-ray Instrumentation
06:49

In situ Grazing Incidence Small Angle X-ray Scattering on Roll-To-Roll Coating of Organic Solar Cells with Laboratory X-ray Instrumentation

Published on: March 2, 2021

6.8K

Modeling of an Active Tablet Coating Process.

Gregor Toschkoff1, Sarah Just2, Klaus Knop2

  • 1Research Center Pharmaceutical Engineering GmbH, Graz, Austria.

Journal of Pharmaceutical Sciences
|September 8, 2015
PubMed
Summary

Optimizing tablet coating uniformity is crucial for pharmaceutical manufacturing. Increasing spray nozzles, rotation speed, and decreasing fill level significantly improve active coating uniformity in discrete element method (DEM) simulations.

Keywords:
coatingfactorial designin silico modelingmathematical modelsimulationstablet

More Related Videos

Fabrication Process of Silicone-based Dielectric Elastomer Actuators
10:32

Fabrication Process of Silicone-based Dielectric Elastomer Actuators

Published on: February 1, 2016

35.0K
Printing Fabrication of Bulk Heterojunction Solar Cells and In Situ Morphology Characterization
07:32

Printing Fabrication of Bulk Heterojunction Solar Cells and In Situ Morphology Characterization

Published on: January 29, 2017

11.7K

Related Experiment Videos

Last Updated: Apr 4, 2026

In situ Grazing Incidence Small Angle X-ray Scattering on Roll-To-Roll Coating of Organic Solar Cells with Laboratory X-ray Instrumentation
06:49

In situ Grazing Incidence Small Angle X-ray Scattering on Roll-To-Roll Coating of Organic Solar Cells with Laboratory X-ray Instrumentation

Published on: March 2, 2021

6.8K
Fabrication Process of Silicone-based Dielectric Elastomer Actuators
10:32

Fabrication Process of Silicone-based Dielectric Elastomer Actuators

Published on: February 1, 2016

35.0K
Printing Fabrication of Bulk Heterojunction Solar Cells and In Situ Morphology Characterization
07:32

Printing Fabrication of Bulk Heterojunction Solar Cells and In Situ Morphology Characterization

Published on: January 29, 2017

11.7K

Area of Science:

  • Pharmaceutical Engineering
  • Computational Fluid Dynamics
  • Process Optimization

Background:

  • Tablet coating is a critical pharmaceutical manufacturing step, especially for active coatings containing pharmaceutical ingredients.
  • Ensuring uniform coating across all tablets in a batch is paramount for drug efficacy and safety.
  • Discrete Element Method (DEM) simulations are increasingly utilized to model and understand complex coating processes.

Purpose of the Study:

  • To investigate the influence of operational parameters on tablet coating uniformity using DEM simulations.
  • To achieve a deeper understanding of the coating process through residence time analysis and dimensionless scaling laws.
  • To identify key factors for improving coating uniformity in active coating processes.

Main Methods:

  • Application of Discrete Element Method (DEM) to model an active tablet coating process with measured parameters and non-spherical particles.
  • Statistical design of (simulation) experiments to plan and interpret simulation runs.
  • Analysis of operational conditions including rotation speed, fill level, number of nozzles, and spray rate.
  • Interpretation of results using analytical models to establish scaling laws.

Main Results:

  • Identified that increasing the number of spray nozzles yielded the most significant improvement in coating uniformity.
  • Found that increasing rotation speed and decreasing fill level also contributed positively to uniformity.
  • Demonstrated the utility of DEM simulations in predicting and optimizing tablet coating processes.

Conclusions:

  • The number of spray nozzles is the most impactful parameter for enhancing active tablet coating uniformity.
  • Process parameters such as rotation speed and fill level offer further opportunities for uniformity optimization.
  • DEM simulations provide valuable insights for designing and controlling pharmaceutical tablet coating operations.