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A Simulation Study of Relative Efficiency and Bias in the Nested Case-Control Study Design

Stephen Bertke1, Misty Hein1, Mary Schubauer-Berigan1

  • 1Centers for Disease Control, National Institute of Occupational Safety and Health, Cincinnati, OH 45226, USA.

Epidemiologic Methods
|September 9, 2015
PubMed
Summary

Sampling more controls per case in nested case-control studies improves efficiency and reduces bias. This is particularly beneficial with few cases, strong exposure-response relationships, and skewed exposure data.

Keywords:
biasefficiencymatched case–control studiesnested case–control studiessimulation

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