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Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from

Linda Petrone1, Angela Cannas1, Francesco Aloi2

  • 1Translational Research Unit, Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases (INMI), 00149 Rome, Italy.

Biomed Research International
|September 9, 2015
PubMed

Insights

Interferon-γ inducible protein 10 (IP-10) shows higher levels in children with respiratory illness but is not an accurate biomarker for diagnosing tuberculosis (TB) in this population. Its utility may be as a general inflammatory marker.

Area of Science:

  • Pediatric infectious diseases
  • Biomarker discovery
  • Immunology

Background:

  • Interferon-γ inducible protein 10 (IP-10) is a potential biomarker for tuberculosis (TB) in adults.
  • Evaluating IP-10's diagnostic potential in children is crucial, especially in high TB-endemic regions like Uganda.

Purpose of the Study:

  • To assess the utility of IP-10 in blood and urine as a diagnostic biomarker for active TB in Ugandan children.
  • To compare IP-10 performance against established TB diagnostic assays (TST and QFT-IT) in pediatric populations.

Main Methods:

  • Prospective enrollment of children with suspected active TB, including those with and without HIV infection.
  • Measurement of IP-10 levels in blood and urine, alongside clinical data and results from TST and QFT-IT assays.
  • Comparison of IP-10 levels between children with active TB and healthy adult donors (HAD).

Main Results:

  • IP-10 was detectable in children with active TB, irrespective of HIV status or age.
  • While IP-10 levels were elevated in active TB cases compared to HAD, diagnostic accuracy was low.
  • The accuracy of IP-10 for diagnosing active TB was comparable to TST and QFT-IT in this pediatric cohort.

Conclusions:

  • IP-10 levels are elevated in children with respiratory illness, not specifically indicative of TB.
  • IP-10 may serve as a general inflammatory marker rather than a specific diagnostic test for childhood TB.
  • Further research is needed to clarify the role of IP-10 in pediatric inflammatory conditions.
Abstract

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