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Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Peptide Identification Using Tandem Mass Spectrometry01:33

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
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Murine Model of Allergen Induced Asthma
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Deciphering Asthma Biomarkers with Protein Profiling Technology.

Zhizhou Kuang1, Jarad J Wilson2, Shuhong Luo1

  • 1RayBiotech, Inc., Guangzhou 510600, China ; RayBiotech, Inc., 3607 Parkway Lane, Norcross, GA 30092, USA ; South China Biochip Research Center, Guangzhou 510600, China.

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Asthma is a complex airway inflammation with many variants, making diagnosis difficult. Protein biomarkers and advanced testing offer new hope for improved asthma diagnosis and treatment.

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Area of Science:

  • Immunology
  • Pulmonology
  • Biomarker Discovery

Background:

  • Asthma is a chronic inflammatory airway disease characterized by bronchial hyperresponsiveness.
  • It presents as a multifaceted syndrome with diverse underlying biologic mechanisms and inflammatory phenotypes.
  • These complexities complicate accurate diagnosis and effective treatment strategies.

Purpose of the Study:

  • To review potential protein biomarkers in asthma pathogenesis.
  • To discuss the utilization of these biomarkers in current research.
  • To explore how advanced testing methods can improve asthma diagnosis and patient care.

Main Methods:

  • Review of current literature on asthma biomarkers.
  • Discussion of protein biomarker detection platforms, including cytokine antibody arrays.
  • Analysis of pathophysiologic and etiologic factors in asthma variants.

Main Results:

  • Protein biomarkers are crucial tools for asthma research and clinical applications.
  • Cytokine antibody arrays facilitate global analysis in asthma biomarker studies.
  • Understanding diverse asthma phenotypes is key to biomarker identification.

Conclusions:

  • Protein biomarkers hold significant potential for improving asthma diagnosis.
  • Further development in testing methodologies is essential for better patient outcomes.
  • Targeted biomarker approaches may alleviate the treatment strain on asthma patients.