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Toward an integrative science of the developing human mind and brain: Focus on the developing cortex
Terry L Jernigan1, Timothy T Brown2, Hauke Bartsch3
1Center for Human Development, University of California, San Diego, La Jolla, CA, United States; Department of Cognitive Science, University of California, San Diego, La Jolla, CA, United States; Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States; Department of Radiology, University of California, San Diego, La Jolla, CA, United States.
Integrating developmental neurobiology and cognitive neuroscience is crucial. Large-scale research is needed to link brain imaging biomarkers to cellular changes and understand child development.
Area of Science:
- Developmental neuroscience
- Cognitive neuroscience
- Neuroimaging genetics
Background:
- Early observations noted variability in synaptic density and cortical volume reductions in developing brains.
- Despite advances, the relationship between these early findings remains unclear.
Purpose of the Study:
- To highlight the need for an integrative scientific paradigm.
- To propose large-scale collaborative research for understanding brain development.
Main Methods:
- Review of key observations in developmental neurobiology and cognitive neuroscience.
- Illustration with data from the Pediatric Imaging, Neurocognition, and Genetics Project (PING).
Main Results:
- Progress in understanding brain development has been made.
- Challenges remain in linking behavioral differences to imaging biomarkers and cellular changes.
Conclusions:
- An integrative approach is essential for addressing complex questions in child brain development.
- Collaborative research is vital to connect macro-level observations with micro-level cellular changes.
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10:25Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
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