Related Experiment Video
Updated: Apr 4, 2026

Adeno-associated Virus-mediated Transgene Expression in Genetically Defined Neurons of the Spinal Cord
Published on: May 12, 2018
Conus Medullaris Level in Vertebral Columns With Lumbosacral Transitional Vertebra
Amir Kershenovich1, Oscar Malo Macias, Faiz Syed
1*Department of Neurosurgery, Geisinger Health System, Danville, Pennsylvania;‡Temple School of Medicine, Philadelphia, Pennsylvania;§Department of Neurosurgery, Hospital 20 de Noviembre, ISSSTE, Mexico City, Mexico;¶Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico;‖Department of Radiology, Geisinger Health System, Danville, Pennsylvania.
Lumbar or sacral transitional vertebrae (LSTV) affect conus medullaris (CM) position. Lumbarization lowers CM to L1-L2, while sacralization raises it to T12-L1, independent of age or sex.
Area of Science:
- Spinal anatomy
- Radiology
- Vertebral anomalies
Background:
- Lumbar or sacral transitional vertebrae (LSTV) affect 4-30% of the population.
- Limited research exists on the conus medullaris (CM) level in individuals with LSTV.
Purpose of the Study:
- To investigate if LSTV influences the position of the CM within the spinal canal across all age groups.
- To compare CM position in patients with LSTV to the general population with normal vertebral columns.
Main Methods:
- Retrospective analysis of spinal MRI scans from a 10-year period.
- Inclusion of patients of all ages, sexes, and pathologies with LSTV.
- Categorization of LSTV into lumbarized (57%) and sacralized (43%) types.
Main Results:
- Lumbarized vertebrae were associated with a lower CM position (mean L1-L2).
- Sacralized vertebrae were associated with a higher CM position (mean T12-L1).
- CM level distribution was consistent across sexes and ages, excluding tethered cords.
Conclusions:
- LSTV type significantly impacts CM position: lumbarization lowers it, sacralization raises it.
- CM level is not affected by patient age, sex, or most pathologies.
- Findings provide crucial anatomical insights for conditions related to LSTV.
Related Concept Videos
Spinal Cord: Gross Anatomy
Vertebral Column: Regions and Curvature
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form...
General Structure of a Vertebra
Articulations of the Vertebral Column
Spinal Cord: Cross-sectional Anatomy
Gray Matter and its Components
Central to the gray matter is...
Muscles of the Vertebral Column
Superficial Layer:
The superficial layer consists primarily of the splenius muscles, which include the splenius capitis and splenius cervicis. These muscles are mainly responsible for the head and cervical spine movements, including extension, rotation, and lateral bending. The splenius capitis...

