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Updated: Dec 16, 2025

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

Neuroblastoma.

Johannes Hubertus Schulte¹, Angelika Eggert¹

¹Department of Pediatric Oncology and Haematology, University Children's Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), Berlin, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

Critical Reviews in Oncogenesis

|September 10, 2015

Summary

This summary is machine-generated.

Neuroblastoma, a common childhood cancer, presents unique clinical challenges. Research advances in developmental biology and genomics have revealed key pathways and potential therapeutic targets for this enigmatic tumor.

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Zebrafish Model of Neuroblastoma Metastasis

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

Area of Science:

Pediatric Oncology
Developmental Biology
Cancer Genomics

Background:

Neuroblastoma is the most frequent pediatric extracranial solid tumor.
Its complex clinical behavior has historically challenged effective treatment strategies.
Understanding its origins is crucial for developing targeted therapies.

Purpose of the Study:

To provide an overview of neuroblastoma's clinical features and current treatments.
To highlight recent advancements in understanding neuroblastoma pathogenesis.
To identify potential therapeutic targets based on molecular insights.

Main Methods:

Review of clinical features and therapeutic approaches.
Analysis of sympathoadrenal developmental biology.
Integration of transcriptome, next-generation sequencing, GWAS, and epigenetic data.

Main Results:

Illumination of critical signal transduction pathways in neuroblastoma.
Identification of therapeutically actionable targets.
Enhanced understanding of tumor biology through multi-omics approaches.

Conclusions:

Advances in molecular biology and genomics have significantly improved our understanding of neuroblastoma.
Targeted therapies based on identified pathways offer promising avenues for clinical development.
Continued research is essential for overcoming the challenges posed by this pediatric cancer.