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The antihypoxic effect of ethymisole: a comparison with other nootropic drugs
H D Fischer1, C Wustmann, E Rudolph
1Institute of Pharmacology and Toxicology, Medical Academy, Carl Gustav Carus, Dresden, GDR.
Biomedica Biochimica Acta
|January 1, 1989
Abstract:
Ethymisole reveals a potent antihypoxic effect which is produced probably both by an acute free radical scavenging property and a persisting restitutive component of action. This is seen in its effect on posthypoxic inhibition of dopamine release from striatum slices of adult rats. Though ethymisole is considered a drug which increases brain adaptive potency, it does not modify the stimulus-response relation of potassium-evoked dopamine release in an adaptation-like manner, as it is seen after a long-lasting piracetam treatment.