Related Experiment Video
Updated: Apr 4, 2026
05:07
Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice
Published on: August 25, 2023
2.2K
Peripheral microcirculatory hemodynamic changes in patients with myocardial ischemia
Zehava Ovadia-Blechman1, Idit Avrahami2, Einat Weizman-Shammai3
1Department of Medical Engineering, Afeka Tel Aviv Academic College of Engineering, 218 Bney-Efraim Rd., Tel Aviv, Israel; Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel-Hashomer, Israel.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|September 10, 2015
Summary
Peripheral microcirculation monitoring shows promise for diagnosing myocardial ischemia. This non-invasive method detects changes in skin blood flow, aiding in the assessment of ischemic heart disease.
Area of Science:
- Cardiology
- Biomedical Engineering
- Physiology
Background:
- Coronary heart disease (CHD) is associated with altered skin microcirculation and reduced cutaneous blood volume.
- Assessing peripheral microvascular function offers a potential avenue for understanding systemic effects of cardiac conditions.
Purpose of the Study:
- To evaluate the feasibility of diagnosing myocardial ischemia using peripheral microcirculatory measurements.
- To explore the utility of non-invasive techniques for assessing cardiac health.
Main Methods:
- Utilized a Laser Doppler Flowmeter (LDF), photoplethysmograph (PPG), and transcutaneous oxygen tension (tc-PO2) device for skin microcirculation assessment.
- Monitored heart rate and blood pressure alongside microcirculatory variables before and after exercise stress tests.
- Classified subjects into ischemic (n=20) and non-ischemic (n=27) groups based on myocardial perfusion imaging (MPI).
Main Results:
- Significant differences in Laser-based peripheral variables were observed between ischemic and non-ischemic groups post-exercise.
- No significant differences in central hemodynamic variables (heart rate, blood pressure) were detected between the groups.
Conclusions:
- Peripheral microcirculatory variables demonstrate potential for the non-invasive assessment of myocardial ischemia.
- The LPT system shows clinical promise for sensitive, non-invasive monitoring in healthcare settings and home care for patients with ischemic heart disease.
