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Related Concept Videos

Biofilms01:29

Biofilms

1.9K
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
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Antifungal Agents01:15

Antifungal Agents

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms
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Candida Biofilms: Development, Architecture, and Resistance.

Jyotsna Chandra1, Pranab K Mukherjee1

  • 1Center for Medical Mycology and Mycology Reference Laboratory, Department of Dermatology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106.

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Fungal biofilms, particularly Candida biofilms, are microbial communities on medical devices that resist antimicrobial agents. This review updates knowledge on their development, structure, and resistance mechanisms.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biotechnology

Background:

  • Intravascular device-related infections are frequently linked to microbial biofilms.
  • Candida species are primary fungal pathogens forming biofilms on medical devices and in infections like fungal keratitis.
  • Biofilms exhibit reduced susceptibility to antimicrobials, leading to persistent infections.

Purpose of the Study:

  • To provide an updated overview of fungal biofilms, with a focus on Candida species.
  • To discuss the development, architecture, and resistance mechanisms of these biofilms.

Main Methods:

  • Review of recent technological advancements in biofilm research.
  • Analysis of studies investigating factors influencing biofilm formation (growth time, nutrients, physiological conditions).
  • Synthesis of current knowledge on fungal biofilm characteristics.

Main Results:

  • Biofilm formation is influenced by various environmental and physiological factors.
  • Candida biofilms display complex architecture and specific resistance mechanisms.
  • Novel approaches are enhancing the understanding of biofilm development and markers.

Conclusions:

  • Fungal biofilms pose significant challenges in treating device-related infections.
  • Understanding biofilm development and resistance is crucial for developing effective therapeutic strategies.
  • Continued research is essential for combating persistent fungal biofilm infections.