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Published on: April 21, 2022
Associations between urinary phthalate concentrations and semen quality parameters in a general population
M S Bloom1, B W Whitcomb2, Z Chen3
1Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, NY 12144, USA Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY 12144, USA mbloom@albany.edu.
Urinary phthalate metabolites are linked to reduced sperm counts and abnormal sperm morphology in men. These findings raise concerns about potential impacts on male reproductive health and fertility.
Area of Science:
- Environmental health
- Reproductive toxicology
- Human reproduction
Background:
- Phthalates are implicated as anti-androgens in animal studies.
- Previous research on infertile men suggests phthalates affect semen quality.
Purpose of the Study:
- To investigate the association between urinary phthalate concentrations and semen quality in the general male population.
Main Methods:
- Prospective cohort study of 501 men from the general population.
- Urine and semen samples analyzed for phthalate metabolites and 34 semen quality parameters.
- High-performance liquid chromatography coupled to tandem mass spectrometry used for phthalate analysis.
Main Results:
- Specific phthalate metabolites (MCMHP, MEHHP, MBzP, MNP) associated with lower sperm counts and larger sperm head size.
- MMP and MCPP linked to reduced sperm motility, while MEHP associated with increased sperm motility.
- Observed associations with various sperm morphology changes.
Conclusions:
- Urinary phthalate metabolites are associated with altered semen quality parameters.
- Further research is needed to establish implications for couple fecundity and fertility.
- Findings require cautious interpretation due to single phthalate measurements and lack of multiple comparison correction.
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