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Statins decrease the risk of stroke in individuals with heterozygous familial hypercholesterolemia: A systematic

Fotios Barkas1, Moses Elisaf1, Haralampos Milionis1

  • 1Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.

Atherosclerosis
|September 10, 2015
PubMed
Summary

Familial hypercholesterolemia (FH) significantly increased stroke risk before statin therapy. The introduction of statins dramatically reduced this risk in individuals with heterozygous FH.

Keywords:
Brain infarctionCerebrovascular diseaseFamilial hypercholesterolemiaInherited dyslipidemiaIschemic strokeStatin treatment

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Area of Science:

  • Cardiovascular Epidemiology
  • Genetic Lipid Disorders

Background:

  • Familial hypercholesterolemia (FH) is linked to premature heart disease.
  • The association between FH and stroke risk remains debated.

Purpose of the Study:

  • To conduct a meta-analysis on stroke incidence in heterozygous FH (HeFH) patients.
  • To evaluate the impact of statin therapy on stroke risk in HeFH.

Main Methods:

  • Systematic review and meta-analysis of four observational studies (3374 participants).
  • Comparison of HeFH patients with the general population as controls.
  • Analysis stratified by prestatin and statin eras (pre- and post-1987).

Main Results:

  • Pre-statin era: HeFH significantly elevated stroke risk (OR = 7.658).
  • Statin era: HeFH showed reduced odds for stroke (OR = 0.251).

Conclusions:

  • HeFH is associated with increased cerebrovascular disease risk.
  • Statin therapy significantly mitigates stroke risk in HeFH patients.