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Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Microtubules in Signaling01:22

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The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Related Experiment Video

Updated: Apr 4, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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[Primary cilia and hedgehog signaling].

Katsunori Fujii

    No to Hattatsu = Brain and Development
    |September 11, 2015
    PubMed
    Summary

    The primary cilium, essential for vertebrate development, houses hedgehog signaling proteins. Defects in these proteins within the primary cilium cause congenital malformations and developmental anomalies.

    Area of Science:

    • Cell Biology
    • Developmental Biology
    • Genetics

    Context:

    • The primary cilium is a crucial organelle in nearly all vertebrate cells.
    • Genetic defects in primary cilium components lead to various congenital malformations.
    • Hedgehog signaling regulates development and is implicated in tumorigenesis.

    Purpose:

    • To elucidate the functional roles of hedgehog-related proteins within the primary cilium.
    • To understand how primary cilia mediate hedgehog signaling.
    • To investigate the link between primary cilia, hedgehog pathway, and developmental anomalies.

    Summary:

    • Primary cilia are non-motile organelles vital for cellular signaling.
    • Hedgehog pathway components (PTCH1, SMO, GLI) translocate into primary cilia upon ligand binding.

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  • This translocation is critical for transducing growth signals and proper vertebrate development.

    • Impact:

    • Understanding primary cilia function is key to addressing developmental disorders.
    • Defects in the primary cilium's hedgehog pathway can cause neural tube defects.
    • Elucidating these roles aids research into developmental anomalies and cancer.