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Alterations in Muscle Tone lll

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...

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Related Experiment Video

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Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

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Corpus Callosum Diffusion Restriction in Neonatal Congenital Myotonic Dystrophy.

Nanoha Sakatani¹, Hiroyuki Ikeda¹, Yuki Inami²

¹Department of Pediatrics, Japanese Red Cross Narita Hospital, Chiba, JPN.

|November 18, 2025

Summary

Congenital myotonic dystrophy (CDM) in neonates can show restricted diffusion in the corpus callosum (CC). This finding may indicate hypoxic-ischemic encephalopathy linked to respiratory failure in this severe form of myotonic dystrophy type 1.

Area of Science:

Neonatal Neurology
Neuroimaging
Genetics

Background:

Congenital myotonic dystrophy type 1 (CDM) is a severe neonatal disorder.

Keywords:

corpus callosum diffusion magnetic resonance imaging myotonic dystrophy newborn infant respiratory insufficiency

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Clinical presentation includes hypotonia, respiratory distress, and feeding difficulties.

Neuroimaging findings in neonates with CDM are infrequently documented.