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An Open-Source Normothermic Perfusion System Designed for Research Scientists
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Versatile minimized system--a step towards safe perfusion.

Y M Ganushchak1, E P J Körver2, Y Yamamoto3

  • 1Department of Cardiothoracic Surgery, Maastricht University Medical Centre and Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands y.ganushchak@mumc.nl.

Perfusion
|September 11, 2015
PubMed
Summary
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Assessment of cardiac load-responsiveness in veno-arterial extracorporeal life support: A case series.

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Oxygen debt repayment in the early phase of veno-arterial extracorporeal membrane oxygenation: a cluster analysis.

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Perfusion·2016

Minimizing cardiopulmonary bypass (CPB) circuits offers benefits but has drawbacks. A new versatile minimized system (VMS) provides the advantages of minimized CPB while retaining the safety and adaptability of conventional systems.

Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Perfusion Technology

Background:

  • Minimized cardiopulmonary bypass (CPB) systems reduce inflammatory responses and transfusion needs.
  • However, minimized CPB systems present challenges including pressure fluctuations, gaseous microemboli risk, and limited adaptability for complications.

Purpose of the Study:

  • To develop a versatile minimized system (VMS) that combines the benefits of minimized CPB with the safety and flexibility of conventional systems.
  • To address the limitations of existing minimized CPB circuits.

Main Methods:

  • Development of a VMS with a 600 ml priming volume.
  • Incorporation of a compliance chamber in the venous line to manage pressure fluctuations and act as a bubble trap.
  • Integration of a parallel, switchable open venous reservoir for cardiotomy suction and easy conversion to an open system.
Keywords:
cardiac surgerycardiopulmonary bypassminimized perfusion systemsafetyversatility

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Main Results:

  • The VMS effectively decreases pressure fluctuations and mitigates risks associated with kinetic-assisted drainage.
  • The system allows for cardiotomy suction and can be readily converted to an open system for managing complications.
  • The VMS maintains the advantages of minimized circuits while offering enhanced safety and versatility.

Conclusions:

  • The developed versatile minimized system (VMS) successfully integrates the advantages of minimized CPB with the adaptability of conventional systems.
  • This innovative VMS enhances patient safety and perfusionist response capabilities during complex cardiac surgeries.