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Immunosuppression associated with chronic inflammation in the tumor microenvironment
Dingzhi Wang1, Raymond N DuBois2
1Laboratory for Inflammation and Cancer, The Biodesign Institute and.
Carcinogenesis
|September 11, 2015
Summary
Chronic inflammation creates an immunosuppressive tumor microenvironment, promoting cancer development. Proinflammatory mediators drive this immunosuppression by recruiting suppressor cells and activating immune checkpoints.
Area of Science:
- Oncology
- Immunology
- Inflammation Research
Background:
- Chronic inflammation is a known driver of cancer development.
- An immunosuppressive microenvironment facilitates tumor formation and progression.
- This environment is marked by inflammatory mediators, suppressor immune cells, and T-cell immune checkpoints.
Purpose of the Study:
- To review recent advances in understanding how immunosuppression contributes to cancer.
- To elucidate the role of proinflammatory mediators in inducing an immunosuppressive microenvironment.
- To highlight the mechanisms involving immunosuppressive cells and immune checkpoint pathways.
Main Methods:
- Literature review of recent scientific advances.
- Analysis of mechanisms linking inflammation, immunosuppression, and cancer.
- Focus on proinflammatory mediators, immunosuppressive cells, and immune checkpoints.
Main Results:
- Chronic inflammation generates an immunosuppressive tumor microenvironment.
- Proinflammatory mediators are key in establishing this immunosuppressive state.
- Immune suppressor cells and activated immune checkpoints are critical components.
Conclusions:
- Immunosuppression driven by chronic inflammation is a significant factor in cancer progression.
- Targeting these inflammatory and immunosuppressive pathways may offer therapeutic strategies.
- Understanding these complex interactions is crucial for developing novel cancer treatments.
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