Related Experiment Video

Updated: Apr 4, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

31.0K

Update on the Development of Anti-Viral Agents Against Hepatitis C

Kristin L Macarthur1, Robert Smolic2, Martina V Smolic2

  • 1Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA02215.

Journal of Clinical and Translational Hepatology
|September 11, 2015
PubMed

Insights

New Hepatitis C virus (HCV) treatments are rapidly evolving. This review covers drug targets in development, clinical trial data, and interferon-free regimens for effective HCV therapy.

Area of Science:

  • Hepatology
  • Virology
  • Pharmacology

Background:

  • Hepatitis C virus (HCV) infection affects 170 million globally.
  • HCV leads to chronic hepatitis, cirrhosis, and liver cancer.
  • Evolving therapeutic strategies aim for higher efficacy and fewer side effects.

Purpose of the Study:

  • To review current and emerging drug targets for HCV treatment.
  • To present clinical trial data on efficacy and side effects.
  • To highlight interferon-free treatment regimens.

Main Methods:

  • Review of agents in all phases of drug development.
  • Analysis of Phase III/IV clinical trial data.
  • Examination of mechanisms of action and resistance.

Main Results:

  • Various direct-acting antiviral agents are in development.
  • Interferon-free regimens show promise with manageable side effects.
  • Data on treatment efficacy and resistance profiles are presented.

Conclusions:

  • Novel therapeutic options for HCV are rapidly advancing.
  • Physicians need to stay updated on new treatment strategies.
  • Effective management of HCV requires knowledge of emerging therapies.
Keywords:
DrugHCVPolymeraseProteaseTriple therapy

More Related Videos

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle09:35

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

14.1K
High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses11:34

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

14.5K

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
42
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
32
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
50.6K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.3K
Subviral Agents01:29

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
823