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Asymmetric linkage disequilibrium: Tools for assessing multiallelic LD
Richard M Single1, Nick Strayer1, Glenys Thomson2
1Department of Mathematics and Statistics, University of Vermont, Burlington, VT, United States.
New asymmetric linkage disequilibrium (ALD) measures offer a more complete description of genetic correlation between loci. Software is now available for computing and visualizing these ALD measures, enhancing genetic association and evolutionary studies.
Area of Science:
- Population Genetics
- Statistical Genetics
Background:
- Standard linkage disequilibrium (LD) measures offer limited insight into the correlation between genetic loci.
- Asymmetric LD (ALD) measures provide a more comprehensive description of LD, especially when loci have different numbers of alleles.
Purpose of the Study:
- To introduce novel software for computing and visualizing asymmetric LD (ALD) measures.
- To demonstrate the utility of ALD measures in analyzing complex genetic data.
Main Methods:
- Development of software for calculating and visualizing ALD measures.
- Application of ALD measures to haplotype frequency data from the National Marrow Donor Program (NMDP).
Main Results:
- The software effectively computes and visualizes ALD, revealing asymmetric LD patterns.
- Analysis of NMDP data quantified the degree of LD asymmetry and its allele-specific effects.
Conclusions:
- ALD measures offer a more detailed understanding of LD structure compared to standard measures.
- The developed software facilitates the application of ALD in genetic association and evolutionary studies, enhancing biological insights.
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