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Related Experiment Video

Updated: Apr 4, 2026

Structured Motor Rehabilitation After Selective Nerve Transfers
09:34

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Long-Term Motor Recovery After Severe Traumatic Brain Injury: Beyond Established Limits.

Ryan C N DʼArcy1, D Stephen Lindsay, Xiaowei Song

  • 1NeuroTech Lab, Surrey Memorial Hospital, Simon Fraser University and Fraser Health Authority, Metro Vancouver, British Columbia, Canada (Drs D'Arcy and Song, Ms Greene, and Messrs Ghosh Hajra and Greene); Institute for Biodiagnostics (Atlantic), National Research Council, Halifax, Nova Scotia, Canada (Drs D'Arcy, Song, Gawryluk, and Mr Ghosh Hajra); Department of Psychology, University of Victoria, Victoria, British Columbia, Canada (Drs Lindsay and Gawryluk and Ms Mayo); Pacific Occupational Therapy Services, Victoria, British Columbia, Canada (Ms Mandziuk); and Department of Medical Imaging, Vancouver Island Health Authority, British Columbia, Canada (Dr Mathieson).

The Journal of Head Trauma Rehabilitation
|September 12, 2015
PubMed
Summary

Severe traumatic brain injury (TBI) recovery can continue for over six years, showing significant neural plasticity and improved motor function. This case study highlights the potential for long-term rehabilitation benefits following TBI.

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Area of Science:

  • Neuroscience
  • Neurorehabilitation
  • Traumatic Brain Injury

Background:

  • Severe traumatic brain injury (TBI) can lead to long-term functional deficits.
  • Understanding neural plasticity is crucial for effective TBI rehabilitation.
  • Limited data exists on recovery trajectories beyond the initial years post-TBI.

Purpose of the Study:

  • To investigate neural plasticity changes and motor recovery in a severe TBI case over six years.
  • To correlate functional magnetic resonance imaging (fMRI) findings with clinical outcomes.
  • To explore the potential for continued recovery in TBI patients.

Main Methods:

  • A case-control study design with longitudinal follow-up exceeding six years.
  • Functional magnetic resonance imaging (fMRI) was used to assess lower limb activation.
  • fMRI data was compared to control subjects and mental imagery tasks.

Main Results:

  • Significant increases in motor recovery and fMRI activation were observed over time.
  • Clinical functional recovery strongly correlated with fMRI motor activation changes.
  • Control subjects showed no significant changes in motor or mental imagery activation.

Conclusions:

  • Motor function recovery and neural plasticity can extend beyond six years post-TBI.
  • Rehabilitative efforts can yield continued physical function benefits for many years.
  • Findings challenge existing assumptions about the timeline of TBI rehabilitation.