Related Experiment Video
Updated: Apr 4, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Bifunctional chelating agents based on ionic carbosilane dendrons with DO3A at the focal point and their complexation
Silvia Moreno1,2, Paula Ortega1,2, Francisco Javier de la Mata1,2
1Departamento de Química Orgánica e Inorgánica, Universidad de Alcalá , Edificio de Farmacia 28871, Alcalá de Henares, Spain.
Abstract:
A synthetic protocol has been designed to incorporate the DO3A ligand to the focal point of cationic or anionic carbosilane dendrons, affording a set of bifunctional chelating agents (BFCAs) useful for potential biomedical applications. The complexation behavior study of ionic BFCAs has been accomplished by UV-vis and electron paramagnetic resonance spectroscopy as well as potentiometric titrations. The presence of the dendron branches modifies the complexation capacity of the macrocyclic ring with respect to that of the 1,4,7,10-tetraazacyclodocecane-N,N',N″,N‴-tetraacetic acid (DOTA) ligand. Also, a different behavior has been observed in the carboxylate-terminated dendrons against analogous sulfonate- or amine-terminated dendrons in the contribution of the branches and peripheral groups to the coordination modes. The presence or not of Cu-S2O2 coordination sites and the generation can be important factors to take into account for considering a particular biomedical application.
More Related Videos
11:04Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
Published on: September 7, 2019
09:12Facet-to-facet Linking of Shape-anisotropic Colloidal Cadmium Chalcogenide Nanostructures
Published on: August 10, 2017
Related Concept Videos
Complexation Equilibria: The Chelate Effect
Extraction: Advanced Methods
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Complexometric Titration: Ligands
EDTA: Chemistry and Properties
Formation of Complex Ions