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Updated: Apr 4, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
[Polypharmacy in the elderly - choosing wisely by using the FORTA list].
Martin Wehling1, Christina Throm1
1Klinische Pharmakologie an der Medizinischen Fakultät Mannheim der Universität Heidelberg.
The Fit fOR The Aged (FORTA) list aids clinicians in optimizing medications for elderly patients with multiple conditions. This evidence-based approach helps prevent undertreatment, overtreatment, and mistreatment, improving geriatric pharmacotherapy.
Area of Science:
- Geriatric Medicine
- Pharmacology
- Clinical Practice Guidelines
Context:
- Multimorbidity and polypharmacy pose significant risks to elderly patients.
- Optimizing medication regimens is crucial for improving health outcomes in older adults.
Purpose:
- To describe the procedural details for the successful application of the Fit fOR The Aged (FORTA) list.
- To illustrate how the FORTA list can guide drug selection and medication management in geriatric patients.
Summary:
- The FORTA list categorizes drugs as indispensable (A), beneficial (B), questionable (C), or to avoid (D) based on age-appropriateness, safety, and efficacy.
- The application involves detailed patient assessment, including disease grading, to guide FORTA-assisted drug selection, preventing overtreatment, undertreatment, and mistreatment.
- Subsequent steps include secondary analyses of dosing and contraindications, with medication schemes updated based on clinical effects and side effects.
Impact:
- Facilitates evidence-based prescribing for the elderly, enhancing medication safety and efficacy.
- Supports clinicians in navigating complex polypharmacy, potentially reducing adverse drug events and healthcare costs.
- Promotes a more personalized and effective approach to pharmacotherapy in geriatric populations.
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Drug Dosing: Geriatric Patients
Pharmacodynamics in Geriatric Patients: Effects of Age
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
