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Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Allergic Reactions02:06

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Overview
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Hypersensitivities01:30

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

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Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
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Updated: Apr 4, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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Contact Dermatitis for the Practicing Allergist.

David I Bernstein1

  • 1Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

The Journal of Allergy and Clinical Immunology. in Practice
|September 13, 2015
PubMed
Summary
This summary is machine-generated.

This updated practice parameter offers guidance for diagnosing allergic contact dermatitis using clinical history, physical exams, and patch testing. It covers metal hypersensitivity, occupational cases, children, and patient education on avoiding sensitizers.

Keywords:
AllergenAllergicAllergyContactDermatitisPatch testSensitizer

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Area of Science:

  • Dermatology
  • Allergology
  • Clinical Practice Guidelines

Background:

  • Allergic contact dermatitis (ACD) is a common skin condition requiring accurate diagnosis and management.
  • Existing practice parameters need regular updates to reflect current evidence and clinical challenges.
  • Healthcare providers require evidence-based tools for managing ACD effectively.

Purpose of the Study:

  • To provide an overview of key recommendations from the updated Contact Dermatitis Practice Parameter.
  • To offer guidance on evaluating patients with suspected allergic contact dermatitis.
  • To present practical advice for clinicians managing diverse ACD cases.

Main Methods:

  • Review and synthesis of evidence supporting the updated practice parameter.
  • Development of recommendations for clinical history, physical examination, and patch testing.
  • Inclusion of specific guidance for metal hypersensitivity, occupational dermatitis, and pediatric cases.

Main Results:

  • The updated parameter emphasizes comprehensive evaluation, including detailed history and physical exams.
  • It provides specific protocols for performing and interpreting closed patch testing.
  • Recommendations address specialized scenarios like prosthetic device reactions, occupational exposures, and childhood ACD.

Conclusions:

  • The Contact Dermatitis Practice Parameter serves as a vital, evidence-based clinical resource for allergists and dermatologists.
  • It enhances the diagnostic and management capabilities for patients with allergic contact dermatitis.
  • Practical patient education strategies for allergen avoidance are integral to the parameter.