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[5-Fluorouracil in trabeculectomy: preliminary report].
Taiwan Yi Xue Hui Za Zhi. Journal of the Formosan Medical Association
|November 1, 1989
Summary
Subconjunctival 5-fluorouracil (5-FU) injections improved trabeculectomy success rates in high-risk glaucoma patients. This adjunctive therapy achieved a 79% success rate, particularly benefiting complex cases like neovascular glaucoma.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Surgical Adjuncts
Context:
- Trabeculectomy is a common glaucoma surgery.
- High-risk patients often have suboptimal surgical outcomes.
- Adjunctive therapies are explored to improve success rates.
Purpose:
- To evaluate the efficacy of subconjunctival 5-fluorouracil (5-FU) injections as an adjunctive therapy in trabeculectomy for high-risk glaucoma.
- To assess the success rate and complications associated with 5-FU injections.
Summary:
- Subconjunctival 5-FU injections were administered to 19 high-risk glaucoma patients post-trabeculectomy.
- Injections were given daily for 5-7 days, extended to 10-14 days if needed.
- The overall success rate (IOP < 22mmHg) was 79% over 8 months.
- Specific success rates included 63% for aphakic glaucoma, 100% for neovascular glaucoma, and 83% for failed filters.
- Complications included corneal epithelial defects and conjunctival leaks.
Impact:
- Subconjunctival 5-FU injections represent a promising adjunctive treatment to enhance trabeculectomy outcomes in challenging glaucoma cases.
- The findings support the use of 5-FU to manage fibrous proliferation and improve surgical success.
- Further research may explore optimal dosing and timing for specific glaucoma subtypes.