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Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the

Correne A DeCarlo1, Stuart W S MacDonald2, David Vergote3

  • 1Department of Psychology, University of Victoria, British Columbia, Canada. decarloc@uvic.ca.

The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
|September 13, 2015
PubMed
Abstract

Insights

Vascular health markers predict mild cognitive impairment (MCI) risk. The apolipoprotein E (APOE) ε4 gene may worsen vascular health

Area of Science:

  • Neuroscience
  • Gerontology
  • Genetics

Background:

  • Mild cognitive impairment (MCI) is a significant risk factor for Alzheimer's disease (AD).
  • Vascular health is crucial in age-related cognitive decline and neurodegeneration.
  • Genetic factors, like APOE and COMT, may influence preclinical cognitive changes.

Purpose of the Study:

  • To investigate the independent and interactive effects of vascular health and genetic markers in predicting MCI.
  • To assess the association of vascular and genetic factors with MCI status and stability over time.

Main Methods:

  • Utilized longitudinal data from the Victoria Longitudinal Study.
  • Included measures of vascular health (e.g., vascular diseases, lung capacity, pulse rate).
  • Assessed genetic risk factors: apolipoprotein E (APOE) and catechol-O-methyltransferase (COMT).
  • Examined associations with cognitive status (not impaired cognitive controls vs. MCI) and transitions over 4 years.

Main Results:

  • Vascular health indicators were independently associated with MCI risk at baseline.
  • Vascular health indicators interacted with APOE ε4 to predict MCI risk.
  • These associations extended to MCI conversion and stability over the follow-up interval.

Conclusions:

  • Specific vascular health markers are predictive of MCI risk in aging populations.
  • The APOE ε4 genotype may exacerbate the risk of MCI associated with poor vascular health.
Keywords:
APOECOMTMild cognitive impairmentVascular healthVictoria Longitudinal Study

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