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Updated: Apr 4, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
What Constitutes an "Adequate" Trial in Migraine Prevention?
Jonathan H Smith1, Todd J Schwedt2
1Department of Neurology, University of Kentucky, 740 S. Limestone, L445, Lexington, KY, 40536, USA. jonathan.smith@uky.edu.
Abstract:
Comprehensively assessing the quality of prior preventive treatment attempts often reveals modifiable variables that may account for treatment failure. Similarly, a comprehensive and systematic approach when planning a preventive medication trial is critical for optimizing the chances of treatment success. In this review, we summarize the key elements to be included when assessing the adequacy of a preventive treatment trial. We have developed and included checklists that can be used by providers to improve their assessments of prior preventive treatment trials and to assist with planning a high-quality treatment trial with a new migraine preventive medication.
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