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Published on: October 13, 2023
Biomarkers for Primary Sjögren's Syndrome
Weiqian Chen1, Heng Cao2, Jin Lin2
1Division of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China; Division of Rheumatology, Penn State University Hershey College of Medicine, Hershey, PA 17033, USA.
Abstract:
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with exocrine gland dysfunction and multi-organ involvement. Recent progress in understanding the pathogenesis of pSS offers an opportunity to find new biomarkers for the diagnosis and assessment of disease activity. Screening noninvasive biomarkers from the saliva and tears has significant potential. The need for specific and sensitive biomarker candidates in pSS is significant. This review aims to summarize recent advances in the identification of biomarkers of Sjögren syndrome, trying to identify reliable, sensitive, and specific biomarkers that can be used to guide treatment decisions.
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