Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

8.1K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.1K
The Tumor Microenvironment02:17

The Tumor Microenvironment

3.1K
3.1K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.4K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.4K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

2.3K
2.3K
Stem Cell Niche01:26

Stem Cell Niche

6.6K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
6.6K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

7.4K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD157<sup>+</sup> vascular endothelial stem cells represent a conserved subpopulation with an angiogenic gene expression profile.

Stem cell reports·2026
Same author

Limitations of the p16-3MR mouse model for detecting and eliminating senescent cells.

EMBO reports·2026
Same author

Transient production of CD157-positive vascular endothelial stem-like cells during human-induced pluripotent stem cell-derived endothelial maturation.

Stem cell research·2026
Same author

Japanese Clinical Practice Guidelines for Vascular Tumors, Vascular Malformations, Lymphatic Malformations, and Lymphangiomatosis 2022.

Journal of plastic and reconstructive surgery·2026
Same author

Japanese clinical practice guidelines for vascular tumors, vascular malformations, lymphatic malformations, and lymphangiomatosis 2022.

Surgery today·2026
Same author

Japanese clinical practice guidelines for vascular tumors, vascular malformations, lymphatic malformations, and lymphangiomatosis 2022.

Japanese journal of radiology·2026

Related Experiment Video

Updated: Apr 4, 2026

Heteromulticellular Stromal Cells in Scaffold-free 3D Cultures of Epithelial Cancer Cells to Drive Invasion
09:18

Heteromulticellular Stromal Cells in Scaffold-free 3D Cultures of Epithelial Cancer Cells to Drive Invasion

Published on: April 4, 2025

1.4K

Tumor microenvironment for cancer stem cells.

Kazuyoshi Kise1, Yumi Kinugasa-Katayama1, Nobuyuki Takakura1

  • 1Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

Advanced Drug Delivery Reviews
|September 13, 2015
PubMed
Summary

Cancer stem cells (CSCs) survive in a specialized microenvironment that protects them from therapies. Understanding CSC niche mechanisms is crucial for developing effective cancer treatments targeting drug resistance.

Keywords:
Cancer stem cellsEndothelial cellsMacrophagesMyofibroblastsNicheTumor microenvironment

More Related Videos

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
05:48

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Published on: March 18, 2014

10.2K
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

9.1K

Related Experiment Videos

Last Updated: Apr 4, 2026

Heteromulticellular Stromal Cells in Scaffold-free 3D Cultures of Epithelial Cancer Cells to Drive Invasion
09:18

Heteromulticellular Stromal Cells in Scaffold-free 3D Cultures of Epithelial Cancer Cells to Drive Invasion

Published on: April 4, 2025

1.4K
Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
05:48

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Published on: March 18, 2014

10.2K
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

9.1K

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Cancer Research

Background:

  • Tumor tissues contain heterogeneous cancer cells, including cancer stem cells (CSCs).
  • CSCs possess self-renewal and differentiation capabilities, contributing to tumor heterogeneity and recurrence.
  • Specific microenvironments, known as CSC niches, are hypothesized to maintain CSC stemness and immature phenotypes.

Purpose of the Study:

  • To investigate the cellular and molecular mechanisms underlying CSC maintenance within their niche.
  • To understand how the CSC niche contributes to CSC drug resistance.
  • To identify potential therapeutic strategies targeting CSCs by understanding niche interactions.

Main Methods:

  • Review of existing literature on CSCs, stem cell niches, and drug resistance.
  • Analysis of cellular components within the CSC niche (e.g., fibroblasts, endothelial cells, immune cells).
  • Exploration of molecular signaling pathways involved in CSC stemness and resistance.

Main Results:

  • The CSC niche comprises various non-cancer cells that can adopt phenotypes supporting CSC survival.
  • These niche-modifying cells may protect CSCs from conventional anticancer therapies.
  • Understanding these interactions is key to overcoming therapeutic resistance.

Conclusions:

  • Targeting the CSC niche and its interactions is essential for eradicating CSCs.
  • Further research into the CSC niche's role in drug resistance is needed.
  • Developing therapies that disrupt the CSC niche microenvironment may enhance treatment efficacy.