In vitro cytotoxicity study for electron beam cured adhesive tape for bio-medical application

A device made for biomedical applications must be biocompatible and biologically safe for use. The used ingredients may leach off a device into adjacent tissue and can harm the body after or during application. In the present study qualitative and quantitative methods were used to assess the cytotoxicity of electron beam (e-beam) cured polyurethane pressure sensitive adhesive (PU-PSA) tape materials made for different biomedical applications. In the qualitative morphological results, it was found that there was no cell lysis or morphological changes in triplicate culture wells of the extract of e-beam cured PU-PSAtape. In the quantitative method of cytotoxicity studies, MTT cell viability (%) for PSA tape samples were >90, i.e., relative value of toxicity was nil. In case of agar overlay test for test samples, the relative value of toxicity was nil, while in filter diffusion score for the test samples was between 0-0.2, hence the relative degree of toxicity was nil.