Related Experiment Video
Updated: Apr 4, 2026
09:47
Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
10.2K
Self-assembled nanostructured aqueous dispersions as dermal delivery systems
Magdalena Hoppel1, Manuel Caneri2, Otto Glatter3
1Research Platform 'Characterisation of Drug Delivery Systems on Skin and Investigations of Involved Mechanisms', University of Vienna, 1090 Vienna, Austria.
International Journal of Pharmaceutics
|September 15, 2015
Summary
The internal structure of self-assembled nanoparticles significantly impacts dermal drug delivery. Emulsified microemulsions enhanced diclofenac sodium delivery compared to cubic or hexagonal phases.
Area of Science:
- Nanotechnology
- Materials Science
- Dermal Drug Delivery
Background:
- Self-assembled nanoparticles offer high interfacial area for loading diverse drugs.
- Monoglyceride-based nanoparticles are explored as carrier systems for active ingredients.
Purpose of the Study:
- Investigate the effect of internal nanostructure on dermal delivery of diclofenac sodium.
- Evaluate different self-assembled phases of oil-loaded nanoparticles.
Main Methods:
- Characterization of nanostructured aqueous dispersions using small-angle X-ray scattering (SAXS).
- Assessment of dermal delivery via Franz-type diffusion cells and in vitro tape stripping on porcine skin.
Main Results:
- Dermal delivery of diclofenac sodium depends on the nanoparticle's internal structure.
- R-(+)-limonene content influences skin permeation.
- Emulsified microemulsions showed superior delivery over cubic and hexagonal phases.
Conclusions:
- The internal nanostructure of monoglyceride-based nanoparticles is crucial for optimizing dermal drug delivery.
- Tailoring the nanostructure, particularly via emulsified microemulsions, can enhance drug permeation.
Related Concept Videos
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
2.0K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
2.0K
01:18Transdermal Drug Delivery Systems
144
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
144
01:23Ophthalmic Drug Delivery Systems
222
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
222
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
113
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
113
01:29The Colloidal State
152
The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called...
152
01:27Drug Delivery Systems: Different Types
254
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
254