MGH-USC Human Connectome Project datasets with ultra-high b-value diffusion MRI

Area of Science:

• Neuroimaging
• Biophysics
• Medical Physics

Background:

• The Human Connectome Project (HCP) developed the MGH-USC CONNECTOM 3T MRI scanner.
• This scanner features a high-strength gradient system (300 mT/m) for advanced in vivo human brain imaging.

Purpose of the Study:

• To demonstrate the capabilities of the novel CONNECTOM gradient system.
• To share ultra-high b-value diffusion MRI data for methodological studies.
• To facilitate advanced diffusion MRI analyses with high diffusion contrast.

Main Methods:

• Acquisition of the MGH-USC Adult Diffusion Dataset (N=35) using the CONNECTOM scanner.
• Minimal preprocessing of diffusion MRI data.
• Data sharing via LONI IDA and ConnectomeDB.

Main Results:

• Demonstration of the ultra-high b-value diffusion MRI data acquisition.
• Successful preprocessing and sharing of the dataset.
• Example data analysis including q-ball Orientation Distribution Function (ODF) reconstruction and tractography.

Conclusions:

• The MGH-USC CONNECTOM scanner provides a powerful tool for advanced diffusion MRI.
• The shared dataset supports methodological research in dMRI analysis.
• Future Lifespan Dataset acquisition will expand research possibilities across age groups.