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Relationship Between Hyperuricemia and Cardiovascular Disease Risk Factors in a Chinese Population: A Cross-Sectional
Pu Su1, Liu Hong2, Yifan Zhao3
1Research Center for Translational Medicine, East Hospital, Tongji University, Shanghai, China (mainland).
Insights
Elevated serum uric acid (SUA) is linked to obesity and high cholesterol in Chinese adults. Managing SUA may help prevent cardiovascular disease complications.
Area of Science:
- Cardiology
- Metabolic Health
- Public Health
Background:
- Hyperuricemia, characterized by elevated serum uric acid (SUA) levels, is increasingly recognized for its potential links to cardiovascular diseases (CVDs).
- Understanding these associations within diverse populations, such as the Chinese population, is crucial for public health initiatives.
Purpose of the Study:
- To investigate the relationship between hyperuricemia and various cardiovascular disease risk factors.
- To analyze these associations in both male and female participants within a Chinese cohort.
Main Methods:
- Utilized data from the Chinese Hyperuricemia and Gout Database.
- Measured serum uric acid (SUA), anthropometric data, blood pressure, and metabolic markers (glucose, cholesterol, triglycerides).
- Employed statistical analyses including t-tests, ANOVA, Pearson's correlation, and multivariate regression models.
Main Results:
- Hyperuricemic men exhibited significantly higher weight, BMI, blood pressure, cholesterol, and triglycerides compared to normouricemic men.
- Hyperuricemic women were older and showed significantly greater weight, BMI, blood pressure, glucose, and triglycerides than normouricemic women.
- Increased SUA levels correlated with higher BMI and triglycerides in both sexes, and with higher cholesterol in men, after adjustments.
Conclusions:
- Elevated serum uric acid concentration is strongly associated with obesity and hyperlipidemia in both men and women.
- These findings highlight the need for increased vigilance regarding cardiovascular complications in patients with hyperuricemia.
- Lowering SUA levels may represent a potential therapeutic target for managing cardiovascular diseases.
Background:
To study the relationship between hyperuricemia and cardiovascular diseases (CVDs) risk factors in a Chinese population.
Material And Methods:
Data analyzed in this study were from the Chinese Hyperuricemia and Gout Database. Indicators of serum uric acid (SUA) level, height, weight, systolic blood pressure (SBP), diastolic blood pressure (DBP), smoking status, alcohol consumption, blood glucose, cholesterol, and triglycerides were measured. T test, one-way analysis of variance, Pearson's correlation, multivariate linear regression, and multivariate logistic regression were used.
Results:
Compared with normouricemic men, hyperuricemic men had greater height (P<0.01), weight (P<0.001), body mass index (BMI) (P<0.001), SBP (P<0.01), DBP (P<0.001), cholesterol (P<0.01), and triglyceride (P<0.001). Compared with normouricemic women, hyperuricemic women were older (P<0.01) and had greater weight (P<0.05), BMI (P<0.01), SBP (P<0.01), DBP (P<0.05), glucose (P<0.05), and triglyceride (P<0.001). In men, an increase of 1 mg/dL in SUA was associated with a 0.279 kg/m2 increase in BMI (P<0.001), a 2.438 mg/dL increase in cholesterol (P<0.05), a 10.358 mg/dL increase in triglyceride (P<0.001), and a 3.1 mg/dL decrease in glucose (P<0.01). In women, an increase of 1 mg/dL SUA was associated with a 0.168 kg/m2 increase in BMI (P<0.01) and a 3.708 mg/dL increase in triglyceride (P<0.01). After adjustment, SUA was strongly associated with obesity and hyperlipidemia in both sexes.
Conclusions:
Elevated serum uric acid concentration was strongly associated with obesity and hyperlipidemia in both men and women. These results indicated that, among hyperuricemia patients, we should pay more attention to the possibility of cardiovascular complications. These results might provide a novel target or a possible new treatment for cardiovascular diseases by lowering the level of serum uric acid.
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