Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

885
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
885
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

1.3K
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
1.3K
Drug Therapy01:28

Drug Therapy

411
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
411
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

402
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
402
Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

2.8K
Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
2.8K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determination of amylose/particulate relationship in hydroxyethylstarch.

PDA journal of pharmaceutical science and technology·2001
Same author

Are microorganisms more effective than plants at competing for nitrogen?

Trends in plant science·2000
Same author

Retraining of a competitive master athlete following traumatic injury: a case study.

Medicine and science in sports and exercise·2000
Same author

Use of transgenic animals for carcinogenicity testing: considerations and implications for risk assessment.

Toxicologic pathology·2000
Same author

Inflammatory reactions associated with a calcium sulfate bone substitute.

Annals of transplantation·2000
Same author

Autologous chondrocyte transplantation for reconstruction of isolated joint defects: the Assaf Harofeh experience.

The Israel Medical Association journal : IMAJ·2000
Same journal

High grade cervical intraepithelial neoplasia positive biopsy: the importance of accurate pre-operative workup.

Minerva ginecologica·2021
Same journal

Efficacy and safety of a novel vaginal medical device in recurrent bacterial vaginosis: a multicenter clinical trial.

Minerva ginecologica·2020
Same journal

[Advisory Board Italiano sulla sindrome dell'ovaio policistico (PCOS): dalle osservazioni all'esperienze cliniche sull'uso del mioinositolo (MYO) e dell'acido alfa-lipoico (ALA) per migliorare i quadri della sindrome].

Minerva ginecologica·2020
Same journal

Update on new imaging technologies in sentinel node detection.

Minerva ginecologica·2020
Same journal

Postoperative pelvic dysfunctions associated with the reconstruction of the pelvic floor.

Minerva ginecologica·2020
Same journal

The role of sentinel-node biopsy in ovarian cancer.

Minerva ginecologica·2020
See all related articles

Related Experiment Video

Updated: Apr 4, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

2.4K

Drug therapy for overactive bladder.

M Izett1, M Zacchè, I Giarenis

  • 1Department of Urogynecology, King's College Hospital NHS Foundation Trust, London, UK - linda@lindacardozo.co.uk.

Minerva Ginecologica
|September 15, 2015
PubMed
Summary
This summary is machine-generated.

Overactive bladder (OAB) affects many worldwide, increasing with age. New treatments like beta-3 agonists and botulinum toxin offer improved options beyond traditional antimuscarinic therapy.

More Related Videos

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
10:26

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

Published on: August 18, 2014

27.0K
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

19.9K

Related Experiment Videos

Last Updated: Apr 4, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

2.4K
Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
10:26

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

Published on: August 18, 2014

27.0K
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

19.9K

Area of Science:

  • Urology
  • Pharmacology
  • Geriatrics

Background:

  • Overactive bladder (OAB) is a prevalent condition with significant global health and economic implications.
  • The health burden of OAB is expected to rise due to increasing global populations of older adults.
  • Current medical management, primarily antimuscarinic therapy, faces challenges with poor patient adherence due to side effects and limited efficacy.

Purpose of the Study:

  • To review the evidence base for current and emerging therapies for overactive bladder.
  • To inform healthcare professionals about novel therapeutic strategies for managing OAB.
  • To explore advancements in drug delivery and combination therapies for improved OAB treatment.

Main Methods:

  • Review of existing literature on overactive bladder treatments.
  • Analysis of evidence supporting pharmacological interventions, including beta-3 adrenoreceptor agonists and botulinum toxin.
  • Exploration of emerging combination therapies and novel drug targets.

Main Results:

  • Antimuscarinic therapy remains a primary treatment but suffers from adherence issues.
  • Beta-3 adrenoreceptor agonists and intradetrusor botulinum toxin show growing evidence of efficacy and safety.
  • Novel agents and alternative delivery methods are under investigation to enhance treatment outcomes.

Conclusions:

  • The therapeutic landscape for overactive bladder is evolving with promising new options.
  • Addressing adherence and efficacy remains crucial for effective OAB management.
  • Emerging therapies offer potential for improved patient care and quality of life in OAB patients.