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Related Concept Videos

Ophthalmic Drug Delivery Systems01:23

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

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Ultrasound Cyclo Plasty in Eyes with Glaucoma
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EX-PRESS Glaucoma Filtration Device: efficacy, safety, and predictability.

Jessica E Chan1, Peter A Netland1

  • 1Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.

Medical Devices (Auckland, N.Z.)
|September 15, 2015
PubMed
Summary

The EX-PRESS Glaucoma Filtration Device offers a safe and effective alternative to traditional trabeculectomy for open-angle glaucoma. It demonstrates comparable efficacy with fewer complications and faster vision recovery.

Keywords:
glaucoma drainage implantmitomycin Csurgerytrabeculectomy

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Area of Science:

  • Ophthalmology
  • Surgical Innovation
  • Glaucoma Management

Background:

  • Trabeculectomy is the established surgical treatment for open-angle glaucoma.
  • Complications associated with trabeculectomy have driven the search for alternative surgical methods.
  • The EX-PRESS Glaucoma Filtration Device represents an alternative surgical option.

Purpose of the Study:

  • To review the efficacy and safety of the EX-PRESS Glaucoma Filtration Device.
  • To compare complication rates between EX-PRESS implantation and trabeculectomy.
  • To evaluate the advantages and disadvantages of the EX-PRESS device.

Main Methods:

  • Literature review of studies comparing EX-PRESS implantation with trabeculectomy.
  • Analysis of surgical technique, vision recovery, intraocular pressure control, and complication rates.
  • Assessment of safety and efficacy data for the EX-PRESS device.

Main Results:

  • EX-PRESS implantation is technically simpler and involves fewer surgical steps than trabeculectomy.
  • Patients experience more rapid vision recovery after EX-PRESS implantation.
  • The EX-PRESS device shows comparable efficacy to trabeculectomy with potentially fewer postoperative complications and more predictable intraocular pressure control.

Conclusions:

  • The EX-PRESS Glaucoma Filtration Device is a safe and effective option for managing open-angle glaucoma.
  • It offers potential benefits over trabeculectomy, including simpler surgery and faster recovery.
  • Further research may solidify its role as a primary surgical treatment.