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Simvastatin Use in Patients with Type 2 Diabetes Mellitus: The Effects on Oxidative Stress

Najah R Hadi1, Mohammad A Abdelhussein2, Ammar R M Rudha1

  • 1Department of Pharmacology, Kufa University, Najaf, Iraq.

Oman Medical Journal
|September 15, 2015
PubMed
Abstract

Insights

Simvastatin treatment significantly reduced oxidative stress and improved serum lipids in patients with type 2 diabetes mellitus (T2DM). This study demonstrates simvastatin

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • Type 2 diabetes mellitus (T2DM) is linked to atherosclerosis, oxidative stress, and dyslipidemia.
  • Oxidative control disturbances and dyslipidemia are key factors in T2DM complications.

Purpose of the Study:

  • To evaluate the benefits of simvastatin in T2DM patients.
  • To assess simvastatin's impact on serum lipids and oxidative damage.

Main Methods:

  • A 12-week randomized controlled trial involving 56 T2DM patients with dyslipidemia.
  • Participants received either simvastatin (20mg/day) or a placebo, alongside glibenclamide.
  • Measurements included blood pressure, pulse rate, serum lipids, and oxidative stress markers.

Main Results:

  • Simvastatin significantly reduced erythrocyte glutathione and malondialdehyde (p<0.001).
  • Improved serum lipid profiles were observed in the simvastatin group.
  • These findings indicate reduced lipid peroxidation and oxidative stress.

Conclusions:

  • Simvastatin demonstrates a beneficial role in managing oxidative stress in T2DM.
  • The drug improves serum lipids and mitigates lipid peroxidation.
  • This highlights simvastatin's potential in T2DM management.
Keywords:
AntioxidantsDiabetes Mellitus, Type 2DyslipidemiasSimvastatin

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