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Related Experiment Video

Updated: Apr 3, 2026

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
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High-Grade Leiomyosarcoma Arising in a Previously Replanted Limb.

Tiffany J Pan1, Liron Pantanowitz2, Kurt R Weiss1

  • 1Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA.

Case Reports in Oncological Medicine
|September 15, 2015
PubMed
Summary

This case report details the first instance of leiomyosarcoma developing in a replanted extremity. The rare sarcoma occurred 24 years after limb replantation following childhood amputation.

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Area of Science:

  • Oncology
  • Orthopedic Surgery
  • Pathology

Background:

  • Sarcomas are rare malignancies with diverse etiologies including genetics, irradiation, viral infections, and immunodeficiency.
  • Development of sarcoma in sites of prior trauma, such as burn scars or fracture sites, is infrequently reported.
  • Leiomyosarcoma is a malignant mesenchymal tumor arising from smooth muscle tissue.

Purpose of the Study:

  • To report the first known case of leiomyosarcoma arising in a replanted extremity.
  • To discuss potential contributing factors for sarcoma development in a replanted limb.
  • To highlight long-term outcomes following surgical resection and multimodal treatment.

Main Methods:

  • Case presentation of a patient with a history of traumatic amputation and subsequent limb replantation.

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Last Updated: Apr 3, 2026

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
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  • Detailed clinical, radiological, and pathological examination of a large forearm mass.
  • Description of the treatment course including surgical resection, brachytherapy, free flap reconstruction, and chemotherapy.

    • Main Results:

    • A high-grade, subfascial spindle cell sarcoma, diagnosed as grade 3 leiomyosarcoma (stage pT2bNxMx), was identified in the replanted forearm.
    • The tumor measured 10.8 cm and was completely resected.
    • The patient remained disease-free with no recurrence at three-year follow-up.

    Conclusions:

    • This is the first reported case of leiomyosarcoma developing in a replanted extremity.
    • Potential etiological factors may include revascularization, scar formation, or chronic injury associated with the replantation.
    • Multimodal treatment can achieve favorable outcomes in rare cases of sarcoma in replanted limbs.