Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

51
Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
51

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial intelligence and machine learning for plasmonic and surface-enhanced sensing.

Chemical Society reviews·2026
Same author

Intracranial Surface-Enhanced Raman Scattering Endoscopy for <i>In Vivo</i> Protein Quantification under Physiological Stimulation.

ACS sensors·2025
Same author

Profile, Infection, and Vaccination Uptake: A Cohort of Canadian Retail Workers During the SARS-CoV-2 Pandemic.

Infectious disease reports·2025
Same author

Bottlebrush Polymer Templates for the Synthesis of Gold Nanostructures and their Applications as Photothermal Agents and SERS Substrates.

Small methods·2025
Same author

Experimental method to assess depth sensing limits of inelastic scattering measurements using spatial-offset Raman spectroscopy imaging.

Journal of biomedical optics·2025
Same author

Opportunities and Challenges of Self-Driving Laboratories for Sensing.

ACS sensors·2025

Related Experiment Video

Updated: Apr 3, 2026

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
06:12

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

2.1K

Compact multi-channel surface plasmon resonance sensor for real-time multi-analyte biosensing.

Yun Liu, Shimeng Chen, Qiang Liu

    Optics Express
    |September 15, 2015
    PubMed
    Summary

    A novel, compact multi-channel surface plasmon resonance (SPR) biosensor uses a tablet for precise, label-free detection of multiple analytes. This cost-effective device enables simultaneous quantitative analysis for point-of-care applications.

    More Related Videos

    Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms
    15:27

    Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms

    Published on: April 17, 2017

    21.6K
    A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
    09:09

    A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

    Published on: November 23, 2015

    9.2K

    Related Experiment Videos

    Last Updated: Apr 3, 2026

    Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
    06:12

    Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

    Published on: March 17, 2023

    2.1K
    Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms
    15:27

    Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms

    Published on: April 17, 2017

    21.6K
    A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
    09:09

    A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

    Published on: November 23, 2015

    9.2K

    Area of Science:

    • Biomedical Engineering
    • Analytical Chemistry
    • Optoelectronics

    Background:

    • Surface Plasmon Resonance (SPR) biosensing offers label-free detection capabilities.
    • Existing SPR systems often require complex, costly, and fragile instrumentation.
    • There is a need for portable, high-throughput, and cost-effective SPR solutions.

    Purpose of the Study:

    • To demonstrate a compact, multi-channel SPR biosensor utilizing a tablet as the measurement platform.
    • To develop a label-free, high-throughput biosensing system using fiber-optic SPR sensors.
    • To enable simultaneous and quantitative detection of multiple analytes for point-of-care applications.

    Main Methods:

    • A multi-channel SPR biosensor was constructed using a bundle of fiber-optic SPR sensors.
    • Illumination was provided by a light-emitting diode (LED) plane light source, and detection was performed using a cordless camera.
    • Reference and control channels were incorporated to enhance accuracy and reliability by compensating for light source fluctuations and bulk refractive index changes.

    Main Results:

    • The biosensor successfully performed multi-analyte detection of immunoglobulin G (IgG) and concanavalin A (Con A).
    • Specific functionalized channels showed distinct responses to their corresponding analytes (e.g., staphylococcal protein A for IgG, ribonuclease B for Con A).
    • A near-linear relative intensity response was observed with respect to analyte concentration, enabling quantitative detection.

    Conclusions:

    • A compact, cost-effective, and reliable multi-channel SPR biosensor was developed using a tablet platform.
    • The system provides precise, label-free, and high-throughput detection suitable for simultaneous quantitative analysis.
    • This technology is well-suited for point-of-care testing, healthcare diagnostics, environmental monitoring, and biomolecular interaction studies.