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MST kinases in development and disease.

Barry J Thompson1, Erik Sahai1

  • 1The Francis Crick Institute, London WC2A 3LY, England, UK barry.thompson@crick.ac.uk erik.sahai@crick.ac.uk.

The Journal of Cell Biology
|September 16, 2015
PubMed
Summary

Mammalian MST kinases regulate cell growth and polarity. This review covers their roles in normal biology and diseases like cancer and autoimmune disorders.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • The mammalian Mastermind-like (MST) kinase family, homologous to Drosophila melanogaster's Hippo kinase, comprises five key proteins: MST1, MST2, MST3, MST4, and Yes-associated protein kinase 1 (YSK1).
  • These kinases are increasingly recognized for their critical roles in fundamental cellular processes.

Purpose of the Study:

  • To provide a comprehensive review of the regulation and diverse functions of mammalian MST kinases.
  • To highlight their involvement in both normal physiological processes and various pathological conditions.

Main Methods:

  • Literature review of existing research on MST kinase family members.
  • Analysis of studies investigating MST kinase regulation and function.
  • Synthesis of data on MST kinases in physiological and disease contexts.

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Main Results:

  • MST kinases are pivotal regulators of cell proliferation, organ size determination, cell migration, and cell polarity.
  • Dysregulation of MST kinase signaling is implicated in the pathogenesis of several diseases.
  • Specific pathologies discussed include cancer, endothelial malformations, and autoimmune diseases.

Conclusions:

  • The MST kinase family plays a crucial role in maintaining cellular homeostasis and organismal development.
  • Understanding MST kinase signaling pathways offers potential therapeutic targets for diseases characterized by aberrant cell growth or polarity.
  • Further research into MST kinase regulation and function is warranted to fully elucidate their contribution to health and disease.