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The effect of diphenylhydantoin on the electroretinogram
P Lachapelle1, L Blain, M G Quigley
1Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.
Documenta Ophthalmologica. Advances in Ophthalmology
|December 1, 1989
Abstract:
Acute administration of diphenylhydantoin (DPH) in rabbits produces a significant increase in the amplitude of the a-wave. A marked increase in the amplitude of the b-wave is also noted but the time course is slower than that for the a-wave. While in controls the oscillatory potential (OP) recordings essentially consist of three major types, recordings taken after DPH injection consist of one major OP (OP2), which appears to be a result of the fusion of the original OP2 with another OP produced by the DPH injection. A similar blend of OPs was also seen in ERGs recorded from three human subjects on DPH therapy.