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Neoplastic lesions induced by 1,3-butadiene in B6C3F1 mice
R A Miller1, R L Melnick, G A Boorman
1Battelle, Pacific Northwest Laboratories, Richland, WA 99352.
Experimental Pathology
|January 1, 1989
Abstract:
1,3-butadiene (CAS No. 106-99-0) was evaluated for carcinogenicity and chronic toxicity by inhalation exposure in B6C3F1 mice because of its high production volume, widespread exposure of workers, and the lack of carcinogenicity and toxicity data (NTP Report #228, 1984). Butadiene (BD) had long been considered to have low toxicity. The long-term studies established that BD is a potent mouse carcinogen with multiple organ carcinogenicity (Huff et al. 1985; Melnick et al. 1988). This paper presents morphological descriptions and illustrations of the neoplastic lesions induced by 1,3-butadiene in B6C3F1 mice.